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Schematic illustration of a knee joint
The main component of synovial fluid is hyaluronic acid. Also in the articular cartilage hyaluronic acid is found in large scale. The high viscosity of the hyaluronic acid is produced by the fact that it is a long-chain high-molecular substance. This ensures viscosity in the joint that sufficient lubricating film exists and the synovial fluid can not flow out of the joint space. Similar to motoroil the hyaluronic acid will change its flow characteristics depending on the load. Thus, in the joint always ensure the optimum lubrication, both during intensive sports as well as quiet activities.
Now if this film lubrication in the joint no longer optimal exist, it can cause painful joint irritation. Early as the mid 30 of hyaluronic acid level decreases in the body. Often, then come on joint problems, e.g. Osteoarthritis and rheumatoid arthritis.
This can be counteracted by administration of hyaluronic acid.
Until now experts often assumed that hyaluronic acid can come only through direct injection into the affected joint, this was refuted by numerous studies:
Dr. Schauss, director of the AIBMR Life Sciences Inc., led in 2004 with the participation of a consortium of researchers from the Life Sciences Division of the American Institute of biosocial and medical research, the National Research Institute for Radiobiology and Radiation Hygiene and the Budapest National Institute for Health a study. The results he presented at the Conference on Experimental Biology, Experimental Biology Federation of American Societies for Experimental Biology.
This study demonstrated that oral hyaluronic acid is absorbed after a single administration and led to the joints and organs. The study showed that after a single oral administration of 3mg about 4.5 billion molecules of hyaluronic acid arrived each knee.
Another study, conducted by K. Dean Reeves, Member of the American Academy of Physical Medicine and Rehabilitation, found that daily oral administration of only 2 mg hyaluronic acid within two months at 17% of subjects and at six months, 28% of subjects to a pain relief led (Physical Magazine, USA, November 2003).
In January 2008, in the Nutrition Journal (UK) published a randomized double-blind study of the effect of orally administered hyaluronic acid for pain relief in osteoarthritis of the knee.
From a total of 20 subjects, all older than 40 years, and with osteoarthritis of the knee, ten received daily 80mg oral hyaluronic acid, the control group received a placebo.
This clinical study can be concluded that daily supplementation with oral hyaluronic acid has been helpful to relieve the pain in the knee and thus improve the quality of life of adults with osteoarthritis of the knee.
